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Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of Zimulti (rimonabant) to the US FDA for use in obese and overweight patients with associated risks factors because of continuing concerns about increased risks for suicidal thoughts among some users. 15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. Rimonabant is not yet accustomed for use in the United States, area it is accepted as Zimulti.

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